Heart Attacks & Genetics: The Deciding Factor
So here I am tonight hashing out some crazy truth about our bodies, to be more specific I’m turning complete focus on the genetic side of things. But I’m still missing another element to the story, ah yes the old saying keep a licking and keeps on ticking…
I believe that meaning usually represents the heart.
So there we go our missing link of the topic now found, and one thing is sure when the topic of heart issues come up it’s usually about maintaining and keeping it healthy or the opposite eating enough crap to clog your arteries eventually leaving you with that weird sensation in your arm (prime indicator of a heart attack).
But we all know right from wrong, well most people in the world does know that is. There is one thing that doesn’t come up much in discussion with heart problems and that’s genetics. Yes that right, genetics does play a key role in all of it. I mean it is a major part of your DNA structure in physical composition (body design and make).
These are the things that your parents pass down their offspring, some kids get good genetics other might not be so lucky if it is a hereditary health issue but that’s how genetics works. It cannot rewrite how it will be written into your DNA, I mean after all it takes two to tangle (Mom & Dad) to produce a child.
In order to exist you have to receive a set of chromosomes (you get 23 pairs / or 46 all together) from both the Father and Mother, so you might receive your Mom’s blue eyes or your Father’s weird shaped nose that’s genetics talking to ya right there!
So predicting what characteristics a child will display more of, will decide on the genetic factor of what he or she will receive more of less from either the Mother or Father. Included in this will also be diseases or aliments if it is a hereditary cause (such as heart disease) it’s part of the total package that makes genetics is simply a force of nature to be reckoned with.
Heart Attacks & Genetics: Why Genes Change?
So whether an offspring receives certain traits from their parents, or if there is a genetic change that can affect the genes directly becomes written into their DNA. You have to understand that your DNA are composed of genes, this is what defines you in every sense of your physiology as a “being” in the living flesh. When genes go through change then this is referred to as an alteration, think of a realtor that is selling a house to home buyer the price for the house is given to you by the realtor which is the final price.
To come up with that price of the home’s value, the realtor however will have to match prices in different locations that may differ for the same house (built identical) that the buyer is trying to buy. So if the house they want is going for $110,000 on the market, but in the next city it’s the same house going for slightly less which is estimated at $104,000. The reason for this change in price can due to the population size in the city (supply & demand of houses), or an expanding job base that will decide the rise or fall of prices in that particular city.
So now that you have a clearer understanding of the term “alteration”, you can better grasp the concept of how genes can become alter from their original state changed to another. If you heard of the word genetic mutation, then you should know that means there is a change in the DNA’s cellular structure (long structured chromosomes).
nucleotides are the different segments of a chromosome (from a single pair to a larger section of chromosome), nucleotides are responsible for a cell’s storage of genetic information. Check out the list of other roles nucleotides play in the formation of both (RNA) and (DNA) development.
nucleotides tasks & composition:
- they come together to form nucleic acids known as ribonucleic acid & deoxyribonucleic acid
- Nucleotides take part in metabolism functioning, cell signaling, and the transferring of both high & metabolic energy electrons
- they are made up of three parts which consist of five-carbon sugar, phosphate, and the nitrogen-rich structure called the “nitrogenous base“
- The five-nitrogenous bases are known as pyrimidines, pyrimidines have one-carbon nitrogen ring bases that consist of thymine & cytosine
- The larger ring structures called purines, are a two-ring structure that consist of both adenine & guanine
Nucleotides are very important players in the involvement of gene function, and make-up the structure and production of both the DNA and RNA. Genetic mutations takes place due to change in Nucleotides (formation and development), there are three categories of mutations (see Point Mutations) that can result from change in the genetic code itself.
Silent Mutation is when change occurs within the DNA sequence, the production of protein is not changed but instead will persist in producing for multiple codons (see codons). Codons are also referred to as “the genetic code”, in short the tRNA binds to and transports the needed amino acid compound to the corresponding mRNA codon. The mutation factor takes place when there is either a disruption or an unbalance that takes place in the genetic code, in the case of silent mutation it happens when multiple genetic codons encode for the same amino acid compound.
Missense Mutation takes place when a stop codon is coded taking the place of an amino acid code, a stop codon can cause for proteins to stop producing or what is known as “the translation process” which results in the amino acid sequence being cut short producing lesser protein (nonfunctional protein).
Nonsense Mutation mutation that changes the stop codon is called a “stop codon mutation”, they produce both partial and nonfunctional proteins this takes place between the coding region of the mRNA which can lead to diseases such as biliary and skin tract cancer or reduction in testosterone levels.
In a situation of a person experiencing heart attack symptoms, can be a direct result from change of one or a few genetic changes that have taken place. Overeating, eating hazardous foods, poor hygiene (not brushing your teeth properly, or washing you hands before eating) factors like this will cause disease sooner or later it’s just a matter of time.
The inheritance factor plays it part from what has been given to us by our parents (genes passed along), they come in the form of chemicals that you identify as DNA. Genes basically instruct cells in your body to produce proteins, the proteins will help to form our physical features as well as help us to physically carry out bodily functions inside of us (such as urination).
You will receive 23 chromosomes each from both Mom and Dad, most heart conditions (genetics) are inherited in a dominant pattern. This disregards the fact that Men or Women are affected different due to gender, it refers to both sexes meaning that any change or mutation cause applies to both male and female.
There are two copies of each single gene (see dominant gene pattern), if one copy is affected by a mutation present in the pattern can be enough to cause a disease. The offset of the disease NOT affecting the offspring can fall on a 50 – 50% chance, that means the offspring can inherit a normal copy of a gene same time not having the risk of developing the condition which means the offspring has two copies of the recessive gene pattern if the mutation was present in the dominant gene pattern.
An example of Dominant & Recessive Gene Traits:
- Dominant Gene is capital letters (BB) *gene version*
- Recessive Gene is lower cased (bb) *gene version*
- Gene Combination can be Dominant and Recessive (Bb) *mixed-gene version
If you have the (Bb) version with your Mother has green eyes having the dominant gene trait, but the Father has blue eyes and his passes a recessive gene trait then you will wind up having green eyes because of the dominant trait passed from your Mother.
If you have both (bb) versions and your parents both have blue eyes, then chances are you will have blue eyes as well due to the recessive gene being the dominate gene trait.
The goes for any diseases passed along from your parents, if one has inherited the dominant gene pattern on the Mother’s side of the family and it is a heart disease condition then there is a chance that you will receive the mutant gene that is written into your DNA for that condition. This is why it is very important to know your family’s history of “health problems” (if any), knowing key information can be disclosed with a heart specialist (contact a cardiologist) to see if you are indeed affected with the condition.
Tests can be conducted (genetic testing), by taking a sample of the person’s DNA to check for any changes that could cause for an inherited heart disease. The term for changes in genes are called pathogenic mutations, or heart health factors that can cause disease.
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